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A recent study published in the journal *Cell* has identified age 50 as a critical turning point in the human aging process, where significant changes in organ and tissue aging accelerate. Researchers, led by Guang-Hui Liu from the Chinese Academy of Sciences, analyzed 516 tissue samples from organ donors aged 14 to 68, revealing that expressions of 48 proteins linked to diseases, including cardiovascular and liver diseases, increase notably around this age. Liu described this period as a "molecular cascade storm," where aging manifests rapidly across various organ systems. The findings highlight the importance of understanding the biochemical changes associated with aging to develop targeted therapies for age-related diseases. Experts emphasize that this research could shift medical focus from reactive treatment to proactive health management, ultimately aiming to enhance quality of life as individuals age. Future studies are encouraged to explore these findings across diverse demographic groups and additional organs. 
Published: Aug 09 2025, 5 pm ISTeznews.inA recent study published in JAMA Cardiology highlights a concerning trend linking reduced physical activity to an increased risk of heart disease, with declines observed approximately 12 years before cardiovascular events. Researchers analyzed data from over 3,000 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study and found that many individuals experienced a significant drop in moderate-to-vigorous physical activity levels from young adulthood to middle age. Notably, Black male participants exhibited a more consistent decline, while Black females reported the lowest activity levels throughout adulthood, underscoring racial disparities in health. Experts emphasize the importance of maintaining physical activity to mitigate cardiovascular risks and advocate for tailored interventions, especially for vulnerable populations. The findings suggest a critical window for preventive measures, as sustained physical activity can influence key health factors like blood pressure and body weight, potentially delaying or preventing heart disease onset.
Published: Aug 08 2025, 11 pm ISTeznews.inResearch over the past decade suggests that a Mediterranean diet, rich in fresh vegetables, fruits, legumes, and oily fish, may significantly enhance health and longevity. Recent studies in 2025 have linked this diet to improved brain health, reduced cancer risk, lower blood pressure, and even alleviation of chronic constipation. Notably, a modified lower-calorie version of the Mediterranean diet has shown promise in weight management and bone density. Variants like the Green Mediterranean diet, which emphasizes plant-based foods and excludes meat, aim to promote both health and environmental sustainability, potentially reducing visceral fat and slowing brain aging. The MIND diet, which combines elements of the Mediterranean and DASH diets, targets cognitive decline specifically. In the latest episode of *In Conversation*, Dr. Thomas Barber, an endocrinology expert, discusses the evidence supporting the Mediterranean diet and shares tips for healthier eating as we age.
Published: Aug 07 2025, 8 pm ISTeznews.inRecent research published in the journal *Cell Metabolism* suggests that muscle loss associated with GLP-1 medications, such as Ozempic, may be less significant than previously believed. While earlier studies indicated that adults taking these medications could lose between 5-15% of their body weight, with 25-39% attributed to muscle loss, the new findings from a mouse model show a lean muscle mass decrease of only about 10%. Notably, this reduction was not solely from skeletal muscles but also included other tissues, such as the liver, which shrank significantly during weight loss—a common phenomenon that can help mitigate fatty liver disease. Experts emphasize the importance of adequate nutrition and specialized care in weight management, calling for further research, including human trials, to better understand the long-term impacts of GLP-1 medications on muscle strength and overall health outcomes.
Published: Aug 07 2025, 3 am ISTeznews.inResearchers at Northwestern University Feinberg School of Medicine have developed a free online tool to help individuals calculate their "heart age," which may differ significantly from their chronological age, potentially increasing their risk for heart disease. The study, published in *JAMA Cardiology*, analyzed data from over 14,000 American adults and found that many had hearts several years older than their actual age, with women averaging a heart age of 55.4 compared to a chronological age of 51.3, and men at 56.7 versus 49.7. The tool aims to provide a more relatable measure of cardiovascular risk, making it easier for patients to understand their health status and motivate lifestyle changes. Cardiologists emphasize the importance of this tool in facilitating discussions about heart health, as it reframes risk in a personal context, encouraging proactive management of health conditions. Further research is needed to refine the concept of heart age and validate its predictive capabilities.
Published: Aug 06 2025, 9 pm ISTeznews.inA recent study published in *Cancer Discovery* suggests that the widely used artificial sweetener sucralose may hinder the effectiveness of immunotherapy in cancer patients. Researchers found that high sucralose intake, particularly in individuals with melanoma or non-small cell lung cancer, correlates with poorer responses to treatment and lower survival rates. The study indicates that sucralose alters gut microbiota, leading to the degradation of arginine, an amino acid vital for T-cell function, which is crucial for combating cancer. While the findings are still preliminary, the researchers recommend that patients minimize their intake of non-nutritive sweeteners, especially sucralose, during immunotherapy. They also suggest that arginine supplementation could potentially counteract the negative effects of sucralose. Experts have praised the study's significance, emphasizing its potential implications for enhancing cancer treatment outcomes. Further research is planned to explore the effects of other non-nutritive sweeteners.
Published: Aug 06 2025, 1 am ISTeznews.inA recent study has established a concerning link between poor sleep patterns and an increased risk of 172 diseases, including dementia, type 2 diabetes, and Parkinson's disease. Conducted by researchers analyzing data from over 88,000 adults in the UK Biobank, the study found that 92 of these diseases had more than 20% of their risk associated with inadequate sleep. Notably, 42 diseases showed at least double the risk due to poor sleep habits. Experts emphasize that while sleep duration is important, sleep regularity may play an even more critical role in health outcomes. The findings highlight the need for targeted interventions to improve sleep quality as a modifiable behavior that can significantly impact overall health. With sleep issues affecting approximately 10% of the global population, experts recommend establishing consistent sleep schedules and creating conducive sleep environments to mitigate these risks.
Published: Aug 04 2025, 10 pm ISTeznews.inA recent meta-analysis has revealed that adhering to the Mediterranean, DASH, or AHEI diets can significantly lower the risk of developing type 2 diabetes. Analyzing medical histories from over 800,000 individuals across 33 studies, researchers found that the DASH diet led to the greatest risk reduction at 23%, followed by the AHEI diet at 21% and the Mediterranean diet at 17%. All three diets emphasize the reduction of unhealthy fats, sugars, and processed foods, focusing instead on whole foods, fruits, and vegetables. Notably, the findings were applicable across diverse ethnic groups, although the statistical significance was less clear for Hispanic and mixed populations, highlighting a need for further research. Experts suggest that while these diets may not reverse diabetes, they can help manage the condition and improve insulin sensitivity, thus reducing its progression.
Published: Aug 04 2025, 2 pm ISTeznews.inA recent study led by researchers at the University of California, San Francisco, has identified a promising combination of two cancer drugs, letrozole and irinotecan, that may help combat Alzheimer’s disease. This approach, known as drug repurposing, leverages existing medications to expedite treatment development. The study, published in the journal *Cell*, found that these drugs could potentially reverse gene expression changes in neurons and glial cells associated with Alzheimer’s. By analyzing electronic medical records, researchers noted that patients taking these medications had a lower risk of developing Alzheimer’s. In mouse models, the drug combination not only improved memory but also reduced amyloid-beta and tau protein levels, key hallmarks of the disease. Experts in the field praised the innovative methodology, highlighting the benefits of repurposing drugs with established safety profiles to accelerate the search for effective Alzheimer's treatments. Further research is needed to fully understand the mechanisms at play.
Published: Aug 03 2025, 1 pm ISTeznews.inA study from Sweden's Karolinska Institutet highlights the significant impact of dietary choices on chronic disease progression among older adults. Researchers examined over 2,400 participants, averaging 71.5 years, over 15 years, categorizing their eating habits into four groups: the healthy MIND, AHEI, and AMED diets, and the pro-inflammatory EDII diet. Findings revealed that those adhering to healthier diets, rich in vegetables, whole grains, and healthy fats, experienced slower progression of chronic diseases like heart disease and dementia, with up to two fewer diseases compared to those with poor dietary habits. Conversely, a diet high in red meat, processed foods, and sugary drinks correlated with increased chronic illness. Experts emphasized the importance of diet as a modifiable risk factor and acknowledged the challenges older adults face in changing long-standing eating patterns, urging a shift towards healthier options to mitigate health risks.
Published: Aug 02 2025, 8 pm IST
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