eznews.inResearchers have developed a new tool aimed at identifying the risk of metastatic hormone-sensitive prostate cancer (mHSPC) at diagnosis, potentially guiding early treatment decisions. This innovative system predicts early responses in prostate-specific antigen (PSA) levels in patients prescribed androgen receptor pathway inhibitors (ARPI), which are increasingly used in prostate cancer treatment. The study, published in Nature Communications, utilized data from three clinical trials, training a multivariable logistic regression model on 1,030 participants and validating it with 688 others. The findings suggest that the tool can effectively identify high-risk patients who may respond poorly to standard therapies, allowing for personalized treatment plans. Experts emphasize the importance of such innovations in enhancing decision-making for prostate cancer management, particularly as the global prevalence of the disease continues to rise. Further validation of the tool in real-world settings is underway, with hopes for its integration into clinical practice and trials. 
Published: Jan 16 2026, 6 pmeznews.inA recent study published in the journal *Science* has uncovered a potential link between beige fat and blood pressure regulation, using genetically modified mice that lacked the ability to form beige fat. Researchers found that these mice exhibited elevated blood pressure and markers associated with white fat, including angiotensinogen, a precursor for a hormone that raises blood pressure. The study highlights the role of the PRDM16 gene in regulating fat types, with the absence of beige fat leading to vascular changes that increase blood pressure sensitivity. Additionally, an enzyme called QSOX1, which is negatively regulated by PRDM16, was found to be overproduced in the absence of beige fat, contributing to hypertension. Experts suggest that this research could pave the way for new therapeutic targets for blood pressure management, emphasizing the need for further investigation into the molecular mechanisms involved and their relevance to human health.
Published: Jan 16 2026, 12 pmeznews.inA recent study published in *Nature Medicine* suggests that short-term calorie restriction could significantly alleviate symptoms of Crohn's disease, affecting approximately one million people in the U.S. The research involved 97 participants with mild-to-moderate Crohn's, who were divided into two groups: one followed a fasting-mimicking diet of 700-1,100 calories for five consecutive days each month, while the control group maintained their usual diet. Results showed that 69.2% of the fasting group achieved a significant reduction in disease activity, compared to 43.8% in the control group. Additionally, inflammatory markers, such as fecal calprotectin, decreased substantially in the fasting group. Experts, including Dr. Thomas Holland, praised the study for combining symptom-based outcomes with objective biological measures, although they noted the need for further research into long-term effects and practical applications in diverse populations.
Published: Jan 15 2026, 5 pmeznews.inRecent studies published in *Nature Communications* and *The BMJ* have linked common food preservatives to an increased risk of type 2 diabetes and certain cancers. The research, which analyzed data from over 108,000 participants in the French NutriNet-Santé cohort, identified 12 preservatives associated with a higher incidence of diabetes and several linked to increased cancer risks, including breast and prostate cancer. Notably, potassium sorbate and total sulfites were highlighted for their potential dangers. While the findings underscore the need to limit preservative intake, experts caution that the studies do not establish causation and acknowledge limitations, such as self-reported dietary data. Nutritionists recommend focusing on whole foods and minimizing processed items to reduce preservative consumption, emphasizing that overall dietary patterns are more crucial than avoiding individual additives.
Published: Jan 15 2026, 3 pmeznews.inOn January 7, 2026, the U.S. Department of Health and Human Services and the USDA released the new Dietary Guidelines for Americans, 2025-2030, emphasizing a shift towards "eating real food." This update prioritizes protein and healthy fats while downplaying whole grains, encouraging the consumption of full-fat dairy and a strict avoidance of added sugars and processed foods. Experts have praised the guidelines for explicitly warning against highly processed items, which are linked to various health issues. However, some nutritionists caution that the increased focus on protein may oversimplify dietary needs, potentially leading to confusion. They advocate for a balanced approach that considers individual health and lifestyle. While the guidelines serve as a roadmap for healthier eating, experts recommend gradual changes, such as reducing processed foods and sugars, and incorporating a variety of whole foods into meals. The guidelines aim to promote better health but require contextual understanding and personalized application.
Published: Jan 14 2026, 11 pmeznews.inA recent study published in the Journal of the American Heart Association has highlighted the benefits of light physical activity, such as walking, for individuals diagnosed with stages 2, 3, or 4 of cardiovascular-kidney-metabolic (CKM) syndrome, a condition affecting approximately 90% of Americans. Researchers found that even modest increases in light exercise could lead to a 14-20% reduction in mortality risk over 14 years. CKM syndrome encompasses heart disease, kidney disease, obesity, and type 2 diabetes. The study's lead author, Joseph Sartini from Johns Hopkins Bloomberg School of Public Health, emphasized that light activity is particularly crucial for patients who may struggle with more intense exercise. Experts agree that these findings validate the importance of accessible movement for improving health outcomes, suggesting a shift in how healthcare professionals counsel patients on physical activity. Future research is encouraged to explore the long-term impacts of light activity on both physical and mental health.
Published: Jan 14 2026, 2 pmeznews.inA recent study has found that high levels of lipoprotein(a) [Lp(a)] significantly increase the 30-year risk of cardiovascular disease (CVD) in healthy women, underscoring the need for routine screening. Conducted by researchers at Brigham and Women’s Hospital and published in JAMA Cardiology, the study followed nearly 28,000 women over almost three decades, revealing that Lp(a) levels above 30 mg/dL correlated with heightened risks of major cardiovascular events, including heart attacks and strokes. While lifestyle changes can mitigate some cardiovascular risks, Lp(a) is primarily genetically determined, limiting the effectiveness of diet and exercise on its levels. Lead author Ask T. Nordestgaard emphasized the importance of early screening for Lp(a) to initiate preventive measures, particularly for individuals with a family history of heart disease. Experts agree that adopting a heart-healthy lifestyle remains crucial for managing overall cardiovascular risk, even for those with elevated Lp(a).
Published: Jan 14 2026, 1 ameznews.inBrazil is home to an unusually high number of centenarians, including three of the world's ten longest-lived males, prompting researchers to explore the genetic and immunological factors contributing to their longevity. A recent study published in Genomic Press highlights that many Brazilians live well beyond 100 years despite limited access to healthcare, suggesting that unique genetic diversity from a mix of ancestral backgrounds may enhance biological resilience. Key findings indicate that supercentenarians maintain efficient protein management and possess adaptive immune systems, which help them avoid age-related diseases. Experts emphasize the importance of lifestyle choices, such as prioritizing metabolic health, engaging in regular physical activity, and fostering strong social ties, as effective strategies for longevity. While research continues to uncover the secrets of Brazil's supercentenarians, adopting healthy habits can benefit individuals worldwide in their quest for a longer, healthier life.
Published: Jan 13 2026, 2 pmeznews.inA recent study published in the *Cochrane Database of Systematic Reviews* has found that exercise may alleviate depression symptoms as effectively as psychological therapy. Researchers analyzed data from 73 randomized controlled trials involving approximately 5,000 adults, revealing that exercise offers a moderate benefit compared to no treatment. This research is particularly significant for the estimated 30% of individuals with depression who are resistant to conventional therapies. Lead author Andrew Clegg emphasized the importance of updating treatment guidelines to include exercise as a viable option. The study also noted that light to moderate intensity workouts are more beneficial than vigorous exercise, and mixed or resistance training programs outperform aerobic exercise alone. Experts advocate for exercise as a complementary treatment, expanding options for patients who may be hesitant to pursue medication or therapy due to stigma or side effects. Further research is needed to explore the efficacy of different exercise types in treating depression.
Published: Jan 13 2026, 2 ameznews.inResearchers have identified a potential new treatment approach for vascular dementia, a condition linked to impaired blood flow in the brain. A study published in the *Proceedings of the National Academy of Sciences* reveals that the protein Piezo1, which regulates blood flow, becomes dysfunctional due to the loss of a specific fat molecule known as PIP₂. By restoring PIP₂ levels, scientists observed improvements in blood flow and cognitive function in preclinical models. Dr. Osama Harraz, a key researcher, emphasized that these findings highlight the importance of neurovascular mechanisms in cognitive decline and suggest that targeting vascular health could slow dementia progression. While the results are promising, experts caution that further research is needed to validate these findings in humans and explore the broader implications for dementia treatment. As the global dementia population is expected to rise significantly, this research could pave the way for innovative therapeutic strategies.
Published: Jan 12 2026, 7 pmFor the fastest, latest, not so wokest news, 'experts say' you need to visit Eznews
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