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A recent systematic review led by researchers from the University of Cambridge and the University of Exeter suggests that common treatments, including anti-inflammatory drugs like ibuprofen, antibiotics, antiviral medications, and vaccines, may be linked to a lower risk of dementia. With over 55 million people affected globally, dementia, particularly Alzheimer's disease, poses a significant health challenge, costing more than $1 trillion annually. While the review highlights potential benefits, experts caution against hastily repurposing these medications for dementia treatment without further research. They emphasize the need for large-scale, longitudinal studies to clarify which specific drugs might effectively reduce dementia risk and to account for individual genetic and lifestyle factors. Despite the promising findings, neurologists stress that lifestyle changes remain the most effective strategy for reducing dementia risk, urging individuals to consult specialists for tailored medication advice.
Published: Jan 22 2025, 9 pmeznews.inResearchers at the Institute of Cancer Research in London have developed a groundbreaking test that predicts colorectal cancer risk in patients with inflammatory bowel disease (IBD) with over 90% accuracy. IBD patients are already screened for colorectal cancer every one to three years through colonoscopies, but detecting pre-cancerous cells can be challenging. The new test, detailed in the journal *Gut*, analyzes genetic changes in biopsy samples to determine cancer risk. Professor Trevor Graham, the study's senior author, emphasized that this test could help identify patients who require surgery to remove their bowel, thus preventing unnecessary procedures for those at low risk. Experts in the field have praised the study's potential to enhance patient care by reducing invasive procedures and anxiety surrounding cancer risk. Future clinical trials aim to validate the test's effectiveness, with hopes of integrating it into NHS practices.
Published: Feb 04 2025, 10 pmeznews.inRecent research has revealed a potential link between oral bacteria and cognitive decline, including conditions like dementia and Alzheimer’s disease. A study published in *PNAS Nexus* analyzed the oral microbiomes of 115 individuals, discovering that certain bacteria, such as *Neisseria*, were associated with better cognitive function, while *Porphyromonas* was linked to mild cognitive impairment. The findings suggest that maintaining oral health could be crucial for brain health, as harmful bacteria may enter the bloodstream through damaged gums and potentially affect brain function. Experts emphasize the importance of a nitrate-rich diet, like the Mediterranean or DASH diets, in promoting beneficial oral bacteria. This research underscores the need for good oral hygiene not only for dental health but also for protecting cognitive function as we age, offering new avenues for mitigating neuroinflammation and sustaining cognitive abilities.
Published: Feb 03 2025, 6 pmeznews.inA recent study published in *Physiological Reports* indicates that an hour of moderate-intensity exercise can significantly reduce hunger sensations in individuals with overweight and obesity. Conducted by researchers from Iran and Australia, the study found that exercise altered levels of appetite-related peptides, with increased production of the appetite-suppressing cytokine interleukin 6 (IL-6) and the hormone-like protein irisin, while decreasing levels of the hunger-stimulating neuropeptide Y (NPY). Eleven metabolically healthy, non-smoking males participated in two trials, one involving 60 minutes of cycling and the other a rest period. Although the appetite suppression was less pronounced than that seen with GLP-1 medications, experts suggest exercise could be a valuable tool in appetite control and weight management. Researchers emphasize the importance of listening to the body's hunger signals post-exercise, as many individuals may overlook these cues.
Published: Feb 03 2025, 7 pmeznews.inA recent systematic review and meta-analysis published in *The American Journal of Clinical Nutrition* indicates that short-term consumption of plant-based meat alternatives may improve cardiometabolic health by lowering total cholesterol by approximately 6% and "bad" LDL cholesterol by around 12% in adults without cardiovascular disease. The findings suggest that substituting meat with these alternatives for up to eight weeks can be beneficial, although weight reduction was minimal at about 1%. The review, which included data from eight studies involving 369 participants, noted that mycoprotein-based products, derived from fungi, showed particularly positive effects on cholesterol levels. However, researchers highlighted the need for long-term studies to fully understand the health impacts of these products, as most trials were industry-funded and had small sample sizes. Experts recommend that while these alternatives can aid in transitioning to plant-based diets, whole, minimally processed foods are the preferred option for long-term health.
Published: Feb 02 2025, 3 pmeznews.inResearchers at the University of Bergen have unveiled the crucial role of nicotinamide adenine dinucleotide (NAD) in the aging process, revealing that mitochondria act as reservoirs for this vital molecule, which is essential for energy production and DNA repair. As NAD levels decline with age, cells may struggle to function properly, potentially leading to age-related diseases. The study indicates that enhancing NAD availability could offer therapeutic avenues to combat aging. Lead researcher Mathias Ziegler noted that while NAD supplementation may not cure diseases, it could slow their progression and alleviate symptoms. Experts emphasize the importance of dietary sources rich in NAD precursors, such as dairy, fish, and green vegetables, alongside regular exercise to support mitochondrial health. However, they caution against intravenous NAD infusions due to infection risks, recommending oral supplements instead, while advising consultation with healthcare professionals before starting any supplementation.
Published: Feb 01 2025, 5 pmeznews.inA recent study published in *Cell Metabolism* has revealed a link between sugary soda consumption and an increased risk of type 2 diabetes, primarily through alterations in the gut microbiome. Researchers identified nine specific bacterial species whose levels were impacted by soda intake, which in turn affected the production of metabolites associated with diabetes risk. Although soda consumption has declined in recent years, it remains a significant source of added sugar in the U.S. The study, which focused on over 16,000 Hispanic/Latino individuals—who have high soda consumption and diabetes prevalence—found that those consuming two or more sodas daily exhibited reduced beneficial gut bacteria and higher levels of harmful metabolites. The findings suggest that monitoring gut microbiome metabolites could offer insights into diabetes prevention and management. Experts recommend healthier beverage alternatives, such as water or low-sugar sparkling drinks, to mitigate these risks.
Published: Feb 01 2025, 1 ameznews.inA significant study from the University of Colorado Anschutz Medical Campus has revealed that heavy cannabis use may adversely affect working memory, a critical cognitive function. Analyzing data from over 1,000 young adults aged 22 to 36, researchers found that 63% of heavy cannabis users exhibited reduced brain activity during memory tasks. While the effects were described as small but consistent, the findings contribute to a growing body of evidence linking regular cannabis use with cognitive impairments, including potential risks for dementia. Previous studies have indicated that cannabis use has surged globally, with approximately 219 million users in 2021, fueled by legalization efforts in various countries. Experts stress the importance of informed discussions regarding cannabis use, especially among those at risk for cognitive decline. The study's results may prompt further research into the long-term impacts of cannabis on memory and cognitive functions.
Published: Jan 31 2025, 11 pmeznews.inA recent study has highlighted a significant link between micronutrient deficiencies and "hidden hunger" in individuals with type 2 diabetes, with nearly 45% of participants exhibiting such deficiencies. Researchers reviewed data from over 52,000 participants across 132 studies, revealing that vitamin D was the most commonly lacking micronutrient, affecting 60.5% of those studied. Other deficiencies included magnesium (42%), vitamin B12 (29%), and iron (28%). Experts suggest that addressing these deficiencies could enhance diabetes management and overall health outcomes. Daya Krishan Mangal, MD, emphasized the need for further research to establish causal relationships and inform treatment protocols. Registered dietitian Monique Richard advised that a balanced diet rich in whole foods, complex carbohydrates, and healthy fats is crucial for preventing and managing diabetes, stressing that supplements cannot fully replace the benefits of nutrients derived from food.
Published: Jan 30 2025, 7 pmeznews.inA recent study has revealed that adherence to a Mediterranean diet may significantly enhance brain health among Hispanic and Latino adults, particularly by preserving white matter integrity, which is crucial for effective communication between brain regions. While the Mediterranean diet is already celebrated for its cardiovascular benefits, researchers found that its positive effects on brain health extend beyond these traditional factors. The analysis, part of the Study of Latinos-Investigation of Neurocognitive Aging Magnetic Resonance Imaging (SOL-INCA-MRI), indicated that a higher adherence to the diet correlated with lower white matter damage and improved structural integrity. Although the study found that cardiovascular health played a role, it suggested that the diet's benefits may also arise from its anti-inflammatory properties. Experts recommend incorporating more fruits, vegetables, whole grains, and omega-3-rich fish into daily diets while reducing unhealthy fats to support cognitive function and overall brain health.
Published: Jan 30 2025, 8 pmeznews.inRecent research has unveiled a potential link between delayed onset of REM sleep and biomarkers associated with Alzheimer’s disease. The study, which involved 128 participants aged 50 and older, found that those taking longer to enter REM sleep exhibited higher levels of amyloid beta and phosphorylated tau (p-tau181), proteins indicative of Alzheimer's, as well as lower levels of brain-derived neurotrophic factor (BDNF). While the findings suggest that REM sleep latency could serve as a marker for early detection of Alzheimer’s, the study's cross-sectional design limits the ability to establish causation. Experts stress the need for further research with larger, more diverse samples to validate these associations. This study shifts focus from slow-wave sleep to the significance of REM sleep in dementia research, highlighting the importance of monitoring sleep patterns in understanding and possibly mitigating Alzheimer’s disease risk.
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