Trending Health

Hydrogel system cuts daily Ozempic or Wegovy use for diabetes

A new drug delivery system has been developed that could reduce the number of injections required to manage type 2 diabetes. The system uses a specially formulated hydrogel that slowly releases GLP-1 agonist medications over several months. In tests on rats, a single injection of the hydrogel delivered medication for 42 days, equivalent to around four months in humans. If confirmed in human trials, this could mean that type 2 diabetes patients would only need three injections per year instead of daily or weekly shots. However, there are concerns about potential adverse effects lasting for the same duration. The hydrogel is a loose mesh of polymer chains, nanoparticles, and drug molecules, and is administered as a small "depot" under the skin. The researchers hope that the hydrogel could provide a more consistent and convenient method of drug delivery for managing diabetes. sources

Nov 30 2023, 10 pm

Air pollution linked to increased risk of Alzheimer's disease

A recent study published in the journal _Neurology_ reveals a strong correlation between exposure to fine particulate air pollution and elevated levels of amyloid plaques in the brain, a known biomarker for Alzheimer's disease. Researchers found that individuals living in areas with high levels of traffic-related air pollution had increased levels of these markers, particularly those lacking a gene variant that raises Alzheimer's risk. Anke Huels, PhD, from Emory University, emphasized the detrimental impact of air pollution on overall health, including respiratory health, skin aging, and now brain health. The study suggests that environmental factors such as air pollution could play a significant role in the development of Alzheimer's disease, especially in individuals without genetic risk factors. Further research is needed to explore the long-term effects of pollution exposure on brain health. sources

Feb 23 2024, 12 am

Hypertension increases heart disease death risk

High blood pressure, or hypertension, has been identified as the leading risk factor for death in Australia over the past 30 years, according to research published in the journal PLOS ONE. Experts suggest that these findings are likely to be similar in the United States, where nearly half of adults have hypertension, with only 22% having their condition under control. The Centers for Disease Control and Prevention reported that hypertension was a primary or contributing cause of nearly 700,000 deaths in the US in 2021. Despite the prevalence of hypertension, experts note that many individuals are unaware of their condition, emphasizing the importance of regular blood pressure checks and lifestyle modifications to prevent and manage hypertension. The global impact of hypertension is significant, with approximately 1.3 billion adults worldwide living with the condition, highlighting the urgent need for improved awareness and management strategies. sources

Feb 22 2024, 1 am

Study: Excess B3 linked to heart disease risk

High levels of niacin, a common B vitamin found in foods like chicken breast, may contribute to cardiovascular disease, according to a recent study by researchers at the Cleveland Clinic Lerner Research Institute. The study, published in _Nature Medicine_, found that excess niacin can trigger vascular inflammation, leading to plaque buildup on artery walls. While niacin is essential for converting food into energy and maintaining skin and nervous system health, the study suggests that high levels of a breakdown product of niacin, called 4PY, are linked to future cardiac events. Dr. Stanley Hazen, lead author of the study, emphasized the need for further research to understand this new pathway and potential interventions to reduce inflammation and prevent heart disease. Other experts caution against routine niacin supplementation and suggest focusing on a diet rich in fruits and vegetables to avoid excess intake. sources

Feb 21 2024, 11 pm

New Diet Reverses Aging by 2.5 Years

A recent study has found that following a fasting-mimicking diet (FMD) could potentially lower the risk for various diseases and even reverse biological aging by 2.5 years. The diet involves consuming formulated food with controlled levels of dietary macros for five days, followed by a normal diet for the rest of the month. Participants in the study who followed this diet showed improvements in insulin resistance, liver fat, inflammation, and other aging markers. The study, conducted by USC Leonard Davis School Professor Valter Longo, involved 100 participants and showed promising results in reducing biological age after just three monthly cycles. While the diet is generally safe, it may not be suitable for pregnant individuals or older adults. Experts recommend incorporating healthy foods like those in a Mediterranean diet throughout the month to maintain overall health. sources

Feb 22 2024, 12 am

Early-onset dementia linked to stress-induced brain cell death

New research suggests that the body's inability to switch off the stress response is linked to brain cell death in neurodegenerative diseases, challenging the conventional belief that protein aggregates in the brain are the direct cause of cell death. The study, published in Nature, identifies the stress response mechanism as the culprit and introduces the potential for new treatment strategies by deactivating the brain's stress response and maintaining the activity of a newly identified protein complex known as SIFI. Lead researcher Michael Rapé highlights the importance of targeting the stress response pathway in treating neurodegenerative diseases, such as early-onset dementia. The findings open up new possibilities for treatment approaches and emphasize the need for further research and clinical trials to explore the impact of stress signaling in prevalent diseases like Alzheimer's and frontotemporal dementia. sources

Feb 21 2024, 10 pm

Exercise and sleep lower IBS risk, study finds

A recent study published in the journal _Gut_ suggests that adopting healthy lifestyle choices, such as not smoking, engaging in high levels of physical activity, and getting 7 to 9 hours of sleep per night, may significantly lower the risk of developing irritable bowel syndrome (IBS). Researchers analyzed data from over 64,000 participants in the UK Biobank and found that the more healthy behaviors individuals engaged in, the lower their risk of developing IBS. Experts emphasize the importance of lifestyle factors in preventing the onset of IBS, with specific focus on stress management and maintaining a balanced diet. While the study provides valuable insights, experts caution that individual triggers and symptoms of IBS can vary, highlighting the need for personalized approaches to managing the condition. sources

Feb 21 2024, 8 am

Lose weight with weekend workouts: 1-2 days per week

A recent study published in the journal Obesity suggests that individuals who are short on time for exercise can still achieve weight loss goals by working out only once or twice a week. Referred to as "weekend warriors," these individuals can shed pounds similar to those who exercise regularly if they meet the recommended time goals. The study, based on data from over 9,600 participants, found that weekend warriors had lower abdominal fat and overall body fat compared to inactive individuals. Experts emphasize the importance of consistency in exercise, suggesting activities like running, climbing, hiking, and cycling. While exercise is beneficial for weight loss, experts also stress the significance of a healthy diet, with a focus on eliminating sugary drinks and processed foods. Ultimately, the key to weight loss success for those with limited time lies in a combination of consistent exercise and a balanced diet. sources

Feb 21 2024, 4 am

Weight loss drugs reduce complications post hip replacement surgery

Semaglutide injections, a component of the Wegovy brand, may offer benefits to individuals undergoing hip replacement surgery, particularly those with obesity. Research indicates that individuals taking semaglutide had comparable or improved postoperative outcomes following a total hip replacement compared to those not using the drug. With approximately 1 million people worldwide undergoing total hip arthroplasty annually, the potential impact of this medication is significant. Studies presented at the American Academy of Orthopaedic Surgeons’ 2024 Annual Meeting explored the effects of semaglutide on postoperative outcomes, with results suggesting that patients with obesity who took semaglutide experienced similar rates of complications as those who did not. These findings have been met with enthusiasm by orthopedic surgeons, offering hope for improved outcomes and increased access to successful hip replacement surgery for individuals struggling with obesity and diabetes. sources

Feb 20 2024, 11 pm

Blood test predicts heart attack risk within 6 months

A recent study from Uppsala University in Sweden has identified blood biomarkers that could potentially predict the risk of a first heart attack, providing an early warning system for preventive measures. The study examined blood samples from over 169,000 European individuals without prior cardiovascular disease, comparing those who experienced a heart attack within six months against healthy individuals. Around 90 molecules were identified as potential biomarkers of an imminent heart attack, with brain natriuretic peptide being the most consistent. The study's senior author, Dr. Johan Sundström, emphasized the importance of further research to determine the significance of these molecules. While a new online tool based on existing blood tests is in development, cardiologists emphasize the need for more discriminatory testing to identify patients at the greatest risk of a heart attack. sources

Feb 20 2024, 10 pm

Regular Exercise May Provide More Health Benefits for Women

A recent study published in the Journal of the American College of Cardiology suggests that women may experience greater cardiovascular benefits from regular exercise than men, with less time required to achieve these benefits. The study, which followed 400,000 men and women over two decades, found that women who exercised regularly were 24% less likely to die from any cause and had a 36% lower risk of fatal cardiovascular events compared to sedentary women. In contrast, men who exercised regularly saw a 15% lower risk of premature death and a 14% lower risk of fatal cardiovascular events. The study emphasizes the importance of regular exercise for women's longevity and highlights the potential for changing preconceived health outcomes. Recommendations for exercise include a combination of aerobic exercise and strength training, with women benefiting more from strength training exercises. Dr. Susan Cheng, a study co-author, hopes that these findings will inspire more women to incorporate extra movement into their lives. sources

Feb 20 2024, 6 am

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