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Men at higher risk for diabetes and complications than women

New research delves into why men tend to develop diabetes at lower BMIs and younger ages than women, with abdominal fat in obese men with type 2 diabetes showing higher insulin resistance and different gene expression levels than women. Men also exhibit a higher level of insulin resistance in their adipose tissue. The study, led by researchers at the Karolinska Institutet in Stockholm, Sweden, suggests that the sex differences in insulin resistance could be targeted with specific interventions to prevent type 2 diabetes. Additionally, a study from Australia indicates that men are at a higher risk of developing complications related to type 1 and type 2 diabetes compared to women. Experts suggest that personalized treatment pathways based on sex differences may be beneficial, with some GLP-1 agonists showing more effectiveness in women. Further research is needed to explore sex and gender differences in therapies and interventions to improve diabetes management. sources

Published:
May 17 2024, 6 pm

Medications like Ozempic aid weight loss before bariatric surgery

A recent study presented at the American Society for Metabolic and Bariatric Surgery's annual scientific meeting suggests that individuals with extreme obesity may benefit from losing weight with GLP-1 agonist medications like Ozempic before undergoing bariatric surgery. The research indicates that weight loss prior to surgery can reduce the risk of complications, particularly for those with a body mass index (BMI) over 70. The study involved 113 participants, with those on multiple medications experiencing the most significant weight loss. Medical professionals emphasize the importance of considering factors beyond BMI, such as ethnicity and muscle mass, when assessing obesity. With obesity affecting 42% of adults in the US and posing various health risks, further research is needed to determine the optimal use of medications like GLP-1s both before and after bariatric surgery. sources

Published:
Jun 15 2024, 2 am

Depression linked to memory decline in older adults

A recent study has revealed a bidirectional relationship between depression and memory loss, suggesting that each condition may exacerbate the other. Researchers found that individuals with greater depressive symptoms experienced accelerated memory decline, while significant memory loss led to higher levels of depressive symptoms. The study, which analyzed data from over 8,000 participants, highlights the overlap in the pathology of depression and memory loss within the brain. These findings could have significant implications for therapeutic interventions for treating both conditions in older adults. Experts suggest that viewing depression and memory loss as interconnected issues may offer new hope for those affected and emphasize the importance of integrated treatment approaches. Suggestions for addressing both conditions simultaneously include physical activity, early screening programs, and interdisciplinary collaboration between psychologists and neurologists. sources

Published:
Jun 15 2024, 2 am

Metformin Slows Colorectal Cancer Growth with MicroRNAs: Study

Metformin, commonly used to treat type 2 diabetes, has shown potential in slowing the growth of colorectal cancer cells by altering microRNAs that target genes, according to a recent study. The drug's anti-cancer properties have been of interest, with researchers finding that metformin's impact on microRNAs may explain its effectiveness against cancer. These findings could pave the way for new RNA therapeutics in cancer prevention and treatment. While the study was conducted on isolated cells, the results suggest that metformin could offer alternative treatments for certain cancers. Despite challenges in the field of miRNA therapeutics, this research marks a significant step towards developing potential cancer treatments using RNA-based approaches. sources

Published:
Jun 15 2024, 3 am

Plant-based ultra-processed foods linked to heart disease, mortality risk

A recent study published in _The Lancet Regional Health - Europe_ suggests that plant-based ultra-processed foods could increase the risk of cardiovascular disease and mortality. The study, conducted by researchers at the University of São Paulo, Brazil, analyzed data from almost 127,000 participants and found that for every 10% increase in calorie intake from plant-based ultra-processed foods, there was a 5% increased risk of cardiovascular disease and a 12% higher risk of death from cardiovascular diseases. Lead study author Fernanda Rauber emphasized the importance of choosing minimally processed plant-based foods for better health outcomes. While plant-based diets are recommended, it is crucial to limit the consumption of all ultra-processed foods, including those that are plant-based, to reduce the risk of cardiovascular disease and mortality. Further research is needed to explore the long-term impacts of plant-based ultra-processed foods on health. sources

Published:
Jun 15 2024, 12 am

17 million US adults at risk of losing statin therapy

A recent study published in _JAMA Internal Medicine_ has found that using the latest risk equations for predicting atherosclerotic cardiovascular disease could result in fewer adults meeting eligibility criteria for primary prevention statin therapy. The study, which looked at two equation sets to measure 10-year cardiovascular disease risk, found that using the PREVENT equations greatly reduced the average estimated risk. The research, which included a weighted sample of 3,785 adults, also noted that the use of PREVENT equations could lead to a general shift into lower-risk categories for many individuals. However, the study has limitations, including the reliance on self-reported data and not accounting for factors like medication adherence or changes in cholesterol levels. Further research is needed to determine the most accurate risk-assessment equations in clinical practice. sources

Published:
Jun 14 2024, 9 pm

New Cause of Inflammatory Bowel Disease Discovered by Scientists

Scientists at the Francis Crick Institute in London have made a breakthrough in understanding the genetic mechanism behind inflammatory bowel disease (IBD) and other autoimmune conditions. By identifying a section of DNA that enhances the activity of a gene called _ETS2_, which plays a crucial role in inflammation, researchers have found existing drugs that could potentially target this pathway and reduce inflammation in patients with IBD. This discovery could lead to the development of more effective treatments for IBD, which affects millions worldwide. While experts acknowledge the significance of these findings, they emphasize the need for further studies to confirm the effectiveness of these medications in patients with IBD. The study's results have the potential to revolutionize the treatment of autoimmune diseases, but researchers caution that careful development is necessary to avoid unintended side effects on other bodily functions. sources

Published:
Jun 14 2024, 6 pm

Non-smoking lung cancer patients struggle with treatment effectiveness

Non-smokers with non-small cell lung cancer (NSCLC) may be resistant to standard treatments due to a combination of genetic mutations, according to researchers from University College London, the Francis Crick Institute, and AstraZeneca. The study, published in _Nature Communications_, found that a mutation in the EGFR gene combined with a mutation in the p53 gene led to the development of drug-resistant tumors in non-smokers with NSCLC. Patients with both mutations had poorer survival rates, with some tumors growing after treatment. Researchers are now working on developing a diagnostic test to detect this dangerous genome doubling and exploring combination therapies to address treatment-resistant cases. Dr. Shuresh Ramalingam of the Winship Cancer Institute highlighted the importance of tailored therapies for NSCLC cases where standard treatments fail, particularly in individuals who have never smoked, a demographic that has seen an increase in lung cancer cases in recent years. sources

Published:
Jun 14 2024, 5 am

Study: High intensity exercise may cause weight gain

A recent animal study suggests that intense exercise may unexpectedly contribute to weight gain by reducing subsequent physical activity and lowering body temperature. This effect is linked to disruptions in the circadian rhythm of the stress hormone corticosterone, impacting physical activity and body temperature. The findings emphasize the importance of considering overall activity levels and hormonal rhythms when designing weight loss programs. While exercise is crucial for maintaining health, intense workouts may lead to decreased physical activity and weight gain. Researchers found that a single session of high-intensity exercise can disrupt corticosterone's circadian rhythm, resulting in reduced physical activity and lower body temperature. Experts recommend a balanced approach to exercise, combining moderate-intensity aerobic exercises with resistance training for sustainable weight loss. sources

Published:
Jun 14 2024, 3 am

Study: 4 lifestyle changes slow Alzheimer's, boost cognitive function

A recent study published in Alzheimer’s Research & Therapy suggests that lifestyle interventions, such as stress management, exercise, and dietary changes, may help improve cognitive function in individuals with early dementia due to Alzheimer’s disease. The study involved a 20-week intervention with participants following a plant-based diet, exercising, managing stress, and attending support group meetings. Results showed improvements in cognitive function in the intervention group compared to the control group, highlighting the potential benefits of non-medication interventions in Alzheimer’s disease. While the research has limitations, such as a small sample size and short intervention period, it provides hope for individuals and caregivers impacted by Alzheimer’s disease and may lead to further research in this area. Experts emphasize the importance of lifestyle modifications in slowing the progression of cognitive decline in Alzheimer’s disease. sources

Published:
Jun 13 2024, 11 pm

Weekly Fatty Fish Intake May Help Prevent MS

A recent study suggests that diet may influence the risk of developing multiple sclerosis (MS), a chronic autoimmune inflammatory illness of the central nervous system. Italian researchers utilized data from the UK Biobank to explore how diet and lifestyle factors could affect MS development. They found that adherence to a Mediterranean diet, including moderate fatty fish consumption, may offer protection against the condition. However, experts caution that the study's observational nature limits the establishment of causality, and potential confounding factors could have influenced the findings. While further research is needed, the study provides valuable insights into the role of dietary patterns in MS onset, paving the way for personalized dietary approaches in MS prevention and management. sources

Published:
Jun 14 2024, 12 am

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