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A recent study from Mass General Brigham has unveiled promising results for treating triple-negative breast cancer (TNBC), a particularly aggressive form of the disease that is challenging to treat due to the absence of hormone receptors. Researchers identified a combination of two inhibitors, AKT and EZH2, which when used together, significantly reduced TNBC cell viability within four days. This dual approach appears to induce cancer cells to revert to a more vulnerable state, enhancing their susceptibility to treatment. The findings, published in *Nature*, suggest the potential for clinical trials to explore this combination as a new therapeutic strategy. Experts highlight the importance of such innovative treatments, especially following recent setbacks in targeted therapies. The study also employed machine learning to identify which patients might benefit most from this combination, indicating a shift towards personalized medicine in cancer treatment. 
Published: Oct 11 2024, 10 pmeznews.inA recent study by the National Institute of Mental Health has found that mindfulness-based stress reduction (MBSR) can be as effective as the antidepressant escitalopram in alleviating anxiety symptoms. Conducted with 276 adults diagnosed with various anxiety disorders, the eight-week trial revealed that while escitalopram initially led to a greater reduction in anxiety, by the end of the study, both treatments showed similar efficacy. Notably, participants in the medication group reported significantly more side effects, with 78.6% experiencing adverse events compared to just 15.4% in the MBSR group. Experts suggest that MBSR, which involves weekly sessions and daily mindfulness practices, may offer a viable alternative for those seeking to avoid medication-related side effects. The findings highlight the importance of personalized treatment options for anxiety disorders, emphasizing mindfulness as a potential therapeutic approach in clinical settings.
Published: Oct 17 2024, 6 pmeznews.inRecent studies have shed light on caffeine's complex relationship with heart health, revealing both potential benefits and risks. Research published in the Journal of Clinical Endocrinology & Metabolism indicates that moderate caffeine intake—around 200-300 mg daily, or approximately 2-3 cups of coffee—can reduce the risk of conditions like type 2 diabetes and coronary heart disease. Conversely, a separate study presented at ACC Asia 2024 found that chronic high caffeine consumption (400 mg or more per day) may elevate blood pressure and heart rates, potentially increasing cardiovascular disease risk. Additionally, a study in the Journal of Stroke linked excessive coffee intake (over four cups daily) to a 37% higher stroke risk. Experts caution that while caffeine may enhance vascular health, its effects are influenced by other compounds in coffee and tea, emphasizing moderation as crucial for maintaining heart health.
Published: Oct 17 2024, 2 pmeznews.inResearchers from the University of Essex have identified a combination of 14 "skinny genes" that may enhance weight loss, according to a study published in *Research Quarterly for Exercise and Sport*. The study involved 38 participants aged 20-40, who were assigned to either an exercise group or a control group over eight weeks. While those with more of these genes lost up to 5 kg compared to 2 kg for those without, scientists emphasized that diet and lifestyle remain crucial for effective weight management. Lead author Dr. Henry Chung noted that these genes, linked to energy metabolism, interact to influence weight loss, but stressed that genetic predisposition does not replace the need for regular exercise and healthy eating. Experts, including bariatric surgeon Dr. Mir Ali, highlighted the multifactorial nature of obesity and the importance of personalized interventions for weight management. Further research is needed to explore the relationship between genetics, diet, and obesity.
Published: Oct 16 2024, 9 pmeznews.inA recent study suggests that a once-a-day investigational medication, AGB101, initially developed for treating seizures, may also slow the progression of Alzheimer's disease in individuals with amnestic mild cognitive impairment who do not carry the ApoE-4 genetic variant. Conducted by researchers from AgeneBio and Johns Hopkins University, the phase 2b HOPE4MCI clinical trial involved 164 participants and found that AGB101 led to a 40% reduction in cognitive decline over 18 months compared to a placebo. The drug appears to mitigate hyperactivity in the hippocampus, a brain region crucial for memory, and significantly reduced atrophy in the entorhinal cortex, an early marker of Alzheimer's progression. Experts emphasize the potential of this treatment approach, highlighting its promise in addressing cognitive impairment and the need for continued research into diverse therapeutic strategies for Alzheimer's disease as global dementia cases are projected to triple by 2050.
Published: Oct 16 2024, 10 pmeznews.inA new scientific statement from the American Heart Association (AHA) highlights a significant connection between cardiovascular diseases, including heart failure and atrial fibrillation, and an increased risk of cognitive decline and dementia. The research underscores how heart health impacts brain function, with conditions like high blood pressure and diabetes contributing to cognitive impairment. In a related study, researchers found that heparin, a common anticoagulant, may delay the onset of Alzheimer’s disease by disrupting harmful protein interactions in the brain, potentially extending the timeframe for diagnosis by about a year. While heparin does not penetrate the brain, its effects on the Apolipoprotein E (ApoE) protein could inform future treatments. Experts caution that while these findings are promising, they do not imply that current heparin formulations can prevent Alzheimer’s, necessitating further investigation into its protective potential against dementia-related strokes.
Published: Oct 16 2024, 5 pmeznews.inA recent study from the University of Waterloo suggests that men and women may benefit from different types of breakfasts due to metabolic differences. The research indicates that men may perform better with carbohydrate-rich meals, while women may thrive on fat-rich breakfasts. This divergence stems from women's ability to store more fat yet burn it faster for energy, influenced by complex life phases such as pregnancy. The study's mathematical model fills gaps in understanding women's metabolic responses, which have historically been under-researched. Senior investigator Anita T. Layton highlighted how these findings could lead to tailored dietary recommendations to optimize health and prevent complications like hyperglycemia. Nutritionist Michelle Routhenstein recommended oatmeal and smoothies for men, while suggesting chia pudding and veggie omelets for women. The study emphasizes the importance of addressing sex differences in nutrition, particularly in light of women's unique biological demands.
Published: Oct 15 2024, 7 pmeznews.inResearchers at Oregon Health and Science University have made significant strides in understanding the human brain's glymphatic system, which plays a crucial role in waste removal, a process vital for brain health and potentially linked to Alzheimer's disease. With approximately 32 million people affected globally by Alzheimer's, a condition characterized by the toxic accumulation of proteins such as beta-amyloid and tau, this study highlights the importance of quality sleep in maintaining efficient waste clearance. Utilizing advanced MRI imaging on five participants undergoing brain surgery, the team demonstrated how fluid circulates through perivascular spaces to clear waste. While the findings are promising, experts like neurologist Clifford Segil caution that the implications for treating cognitive disorders remain uncertain, emphasizing that the study's relevance may be more pronounced in neuro-oncology and infectious diseases rather than in dementia care. Further research is needed to explore these dynamics in healthy individuals and those with cognitive impairments.
Published: Oct 14 2024, 10 pmeznews.inRecent studies have highlighted the significant role of stress and disrupted circadian rhythms in the progression of colorectal cancer, particularly through their effects on the gut microbiome. Research presented at UEG Week 2024 and published in *Science Advances* indicates that chronic stress and circadian disruption can alter gut microbiota, leading to increased intestinal permeability and inflammation, which may exacerbate cancer progression. In mouse models, those exposed to chronic stress showed a higher tumor burden when receiving fecal transplants from stressed mice, underscoring the microbiome's influence. Notably, beneficial bacteria like *Lactobacillus* were found to be lower in stressed groups, while antibiotic treatment negated differences in tumor formation. Researchers propose that supplementing with *Lactobacillus plantarum* during periods of chronic stress could serve as a potential intervention strategy for colorectal cancer, suggesting a link between mental state and cancer prognosis. Further exploration is needed to fully understand these mechanisms.
Published: Oct 13 2024, 11 ameznews.inA recent study published in *BMJ Open* has highlighted the potential benefits of reducing sedentary time for individuals suffering from back pain. Researchers found that participants who decreased their sitting time by 40 minutes daily and increased their moderate to vigorous activity by 20 minutes experienced less worsening of back pain compared to a control group that maintained their sedentary lifestyle. The study involved 64 adults, predominantly overweight and with metabolic syndrome, who were monitored over six months. While the intervention group did not report significant changes in back pain, the control group did experience a notable increase. Experts believe that even modest lifestyle adjustments can aid in managing back pain, though they stress that these changes should be part of a comprehensive treatment plan. The study underscores the importance of reducing sitting time, but further research is needed, particularly in individuals with more severe pain.
Published: Oct 12 2024, 6 pmFor the fastest, latest, not so wokest news, 'experts say' you need to visit Eznews
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