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A recent study published in the *New England Journal of Medicine* has shown promising results for the medication tulisokibart in treating moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The phase 2 trial demonstrated that 26% of participants receiving tulisokibart achieved clinical remission by the 12-week mark, compared to just 1% in the placebo group. Additionally, 66% of those on tulisokibart experienced a clinical response, significantly outpacing the 22% in the placebo cohort. Researchers noted that while the drug showed high efficacy, particularly among those likely to respond, the study's limitations included a small sample size and reliance on participant-reported data. The trial's findings could pave the way for further research and potential FDA approval, as tulisokibart enters phase 3 trials. Experts believe that this targeted therapy could enhance treatment options for patients who have not responded to conventional therapies. 
Published: Oct 01 2024, 9 pmeznews.inA recent study published in the *Journal of the American Heart Association* has revealed a concerning link between insufficient sleep and cognitive decline, particularly in individuals with hypertension. Researchers found that those with high blood pressure who slept less than six hours were more likely to exhibit cognitive impairments and markers of brain aging compared to their normotensive counterparts. This correlation suggests that hypertension may exacerbate the negative effects of short sleep duration on cognitive health. While the study involved 682 participants over 40, it did not establish a direct causal relationship, and some experts caution about the strength of the findings. The results underscore the importance of maintaining healthy blood pressure and adequate sleep, prompting calls for further research into interventions that could mitigate cognitive decline in at-risk populations.
Published: Dec 30 2024, 7 pmeznews.inResearch from Charité – Universitätsmedizin Berlin has highlighted the critical role of deep sleep, or slow-wave sleep, in memory formation. The study, published in *Nature Communications*, reveals that during deep sleep, the brain's neocortex experiences alternating electrical states that enhance synaptic connections, making it more receptive to memory consolidation. This process allows the brain to replay past experiences without external interference, crucial for transferring short-term memories into long-term storage. Neurologist Verna Porter emphasized the importance of healthy sleep patterns in maintaining cognitive function, particularly in dementia patients who often experience disrupted deep sleep. The findings suggest that understanding the mechanisms of deep sleep could lead to preventive strategies against cognitive decline. Experts advocate for further research into enhancing deep sleep as a potential avenue for improving memory retention in at-risk populations, underscoring the need for better sleep management in dementia care.
Published: Dec 29 2024, 10 pmeznews.inNew research published in *The American Journal of Clinical Nutrition* suggests that a low-carbohydrate, high-protein diet may effectively lower cholesterol levels in individuals with type 2 diabetes, a group already at increased risk for heart disease due to high cholesterol. Traditionally, a high-carbohydrate, low-fat diet has been recommended, but recent studies indicate that substituting some carbohydrates with protein and fat could yield better health outcomes. Conducted at Copenhagen University Hospital, the study involved two groups of participants following either a carbohydrate-reduced high-protein diet or a conventional diabetes diet over six weeks. Findings revealed that those on the low-carb diet experienced greater improvements in cholesterol profiles, particularly when weight loss was factored in. Experts emphasize the importance of dietary patterns for managing diabetes and cardiovascular risk, highlighting the need for further research to clarify the long-term benefits of such dietary changes.
Published: Dec 28 2024, 8 pmeznews.inA recent study published in the *Journal of Nutrition, Health and Aging* highlights the importance of breakfast for cardiovascular health in older adults. Conducted at the Hospital del Mar Research Institute in Spain, the research involved 383 participants aged 55 to 75, all with overweight or obesity. The findings suggest that breakfast should provide 20% to 30% of daily energy needs, as consuming less than 20% or more than 30% is linked to increased body mass index (BMI) and waist circumference, along with higher triglycerides and lower "good" HDL cholesterol levels. The study also emphasized food quality, revealing that low-quality breakfasts correlated with adverse metabolic changes. Experts recommend a balanced breakfast rich in lean proteins, fiber, and healthy fats to support heart health. Overall, the study underscores the role of proper breakfast habits in reducing cardiometabolic risks among older adults, advocating for mindful food choices and portion control.
Published: Dec 27 2024, 2 pmeznews.inA recent draft recommendation from the U.S. Preventative Services Task Force has concluded that vitamin D supplements, whether taken alone or with calcium, do not prevent falls or fractures in older adults. This finding, based on an analysis of 20 randomized controlled studies, specifically notes that postmenopausal women and older men with normal vitamin D levels and no prior fractures do not benefit from additional supplementation. The guidelines reflect a shift from previous recommendations, which suggested vitamin D could aid in fracture prevention. Experts emphasize that while vitamin D is essential for various health functions, including bone health, its supplementation should be carefully considered within the broader context of an individual's health needs. Physicians are advised to evaluate dietary intake, exercise, and personal health factors before recommending vitamin D, as recent studies have shown no significant benefits in reducing risks associated with fractures or other health issues.
Published: Dec 26 2024, 4 pmeznews.inA recent study from Spain raises concerns about the health claims of processed foods marketed as "high-protein." Analyzing over 4,300 items from a Spanish food database, researchers found that 90.8% of products with protein claims were classified as "less healthy," often containing high levels of sodium, fat, and sugar. Notably, around 60% of these products had added protein, primarily from plant sources, yet many also contained undesirable nutrients. While protein is essential for health, experts caution against assuming that high-protein labels equate to healthier options. They recommend opting for whole food sources of protein, such as nuts or lean meats, rather than processed items. The study highlights the need for consumers to critically evaluate nutritional labels and consider professional guidance when making dietary choices, as misleading packaging can lead to unhealthy eating habits.
Published: Dec 25 2024, 1 pmeznews.inIn 2024, research highlights the importance of a holistic approach to health, emphasizing brain, heart, and metabolic wellness through sleep, diet, and exercise. A recent podcast episode from _Medical News Today_ outlines three actionable resolutions to enhance well-being as the New Year approaches. Experts urge individuals to set realistic, specific goals rather than overwhelming resolutions, advocating for manageable lifestyle changes. Key findings from 2024 reveal that disrupted sleep in individuals aged 30-40 may lead to memory issues and accelerated brain aging. Additionally, engaging in any form of exercise is linked to brain rejuvenation and potentially increased lifespan, while sedentary behavior raises risks for heart failure. Furthermore, the World Health Organization has released dietary guidelines, stressing the importance of balanced nutrition. For comprehensive strategies on improving sleep, diet, and exercise, listeners are encouraged to explore the full podcast episode.
Published: Dec 24 2024, 8 pmeznews.inA recent study published in *Nutrition Research* suggests that a diet rich in antioxidants and whole, nutrient-dense foods may significantly alleviate chronic pain, particularly among women. The research found that higher diet quality was linked to reduced pain levels, independent of body fat, with women experiencing pain reductions of up to 48% when consuming more "core foods" like fruits and vegetables. Conversely, no significant effects were observed in men. Experts emphasize that a healthy diet can mitigate inflammation and oxidative stress, which are known contributors to pain. They recommend incorporating foods high in omega-3 fatty acids, probiotics, and vitamins while limiting processed foods. The findings support the notion of dietary interventions as a complementary approach to traditional pain management, highlighting the importance of a holistic lifestyle in improving overall well-being and pain levels.
Published: Dec 23 2024, 7 pmeznews.inA recent review published in *Nutrients* underscores the potential link between magnesium levels and cardiovascular health, suggesting that inadequate magnesium intake may elevate the risk of various cardiovascular diseases. The review highlights that many individuals do not meet recommended magnesium levels, which can lead to conditions like hypomagnesemia or chronic latent magnesium deficiency, complicating diagnosis. Research indicates that low magnesium may contribute to inflammatory and oxidative stress, abnormal lipid levels, and endothelial dysfunction. Experts emphasize the importance of dietary magnesium, with over a quarter of adults possibly experiencing mild to moderate deficiency. While magnesium supplementation is considered safe, its efficacy in improving heart health remains uncertain, warranting further randomized controlled trials. Dietitian Karen Z. Berg recommends including magnesium-rich foods, such as dark leafy greens, nuts, and seeds, to support overall health and cardiovascular function.
Published: Dec 22 2024, 1 pmeznews.inA recent narrative review published in the journal *Nutrients* has highlighted the potential benefits of the Mediterranean diet for individuals with Inflammatory Bowel Disease (IBD), which includes conditions like Crohn’s disease and ulcerative colitis. The review identifies key nutrients such as plant-derived proteins, omega-3 polyunsaturated fats, and resveratrol that may alleviate IBD symptoms. It emphasizes the importance of gut microbiota and suggests that the diet's high fiber, fruits, and low processed foods could enhance gut health. While the Mediterranean diet is already recommended for IBD management, the exact mechanisms behind its benefits remain unclear. Experts stress the need for further research, particularly in understanding how these dietary components interact with gut microorganisms. Despite some promising findings, the review acknowledges limitations, including reliance on preclinical data, and calls for more comprehensive studies to deepen understanding of the diet's role in IBD treatment.
Published: Dec 21 2024, 2 pmFor the fastest, latest, not so wokest news, 'experts say' you need to visit Eznews
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