eznews.inNovo Nordisk has announced the early termination of its Evoke trials, which aimed to explore whether the weight-loss drug semaglutide could slow the progression of Alzheimer’s disease. Despite the trials involving 3,808 participants over 156 weeks showing significant reductions in Alzheimer’s biomarkers, they did not demonstrate any reduction in disease progression compared to a placebo. This disappointing outcome has led experts to emphasize the complexity of Alzheimer’s, suggesting that no single treatment approach is likely to be effective. While some researchers express cautious optimism about the potential of GLP-1 agonists in addressing Alzheimer’s through metabolic and inflammatory pathways, they acknowledge the need for further investigation. Future studies may focus on higher doses or preventive trials, and there remains hope that combining GLP-1 agonists with lifestyle modifications could reduce dementia risk before symptoms appear. 
Published: Nov 26 2025, 11 pmeznews.inA recent study published in *JAMA* has shown that the experimental drug enlicitide can significantly lower levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol, by up to 60%. Conducted on 303 participants with heterozygous familial hypercholesterolemia, a genetic condition that leads to high LDL levels, the study found that 58.2% of those taking enlicitide experienced a substantial drop in LDL cholesterol after 24 weeks, compared to a rise in the placebo group. This oral medication could offer a more convenient alternative to existing injectable PCSK9 inhibitors, which have shown similar efficacy. Experts suggest that enlicitide may improve adherence among patients reluctant to receive injections. While the results are promising, further trials are necessary to assess its long-term effectiveness and safety in broader populations, including those without genetic predispositions to high cholesterol.
Published: Nov 26 2025, 2 pmeznews.inA recent study from the Oregon Institute of Occupational Health Sciences suggests that maintaining consistent bedtimes can significantly lower blood pressure throughout the day. In the small proof-of-concept study involving 11 participants, those who adhered to a regular sleep schedule for two weeks experienced an average reduction of 4 mmHg in systolic and 3 mmHg in diastolic blood pressure, comparable to the effects of dietary sodium reduction or exercise. Experts emphasize the importance of sleep in cardiovascular health, noting that irregular sleep patterns can disrupt the body's circadian rhythm and lead to higher blood pressure. The findings indicate that regular sleep habits help the cardiovascular system function more effectively, reducing stress hormones and improving heart health. Researchers recommend keeping bedtimes within a 60-minute window and ensuring 7–9 hours of sleep each night to optimize cardiovascular benefits, particularly for post-menopausal women.
Published: Nov 26 2025, 12 ameznews.inA recent study presented at the Radiological Society of North America's annual meeting has revealed a significant connection between muscle mass, visceral fat, and brain aging. Researchers found that individuals with higher muscle mass and a lower visceral fat-to-muscle ratio tended to have younger-looking brains, suggesting that maintaining muscle mass could be a crucial factor in reducing the risk of brain-related diseases like Alzheimer's. The study, which involved 1,164 healthy adults averaging 55 years old, utilized advanced MRI scans and artificial intelligence to assess body composition and brain age. Lead author Dr. Cyrus A. Raji emphasized that visceral fat, linked to inflammation and metabolic issues, negatively impacts brain health, while higher muscle mass is associated with better overall metabolic health. Experts advocate for lifestyle changes focusing on increasing muscle mass and decreasing visceral fat as promising strategies for enhancing brain resilience and mitigating cognitive decline.
Published: Nov 25 2025, 7 pmeznews.inA recent study published in *The Lancet* highlights the rising consumption of ultra-processed foods (UPFs) globally, linking their intake to an increased risk of 12 health conditions, including Crohn’s disease and diabetes. This research, part of a three-paper series, reveals that UPFs now account for over 50% of total food purchases in the US and UK, with significant increases noted in Spain, China, Mexico, and Brazil. The study's lead author, Carlos A. Monteiro, emphasizes that powerful corporations promote these foods, undermining public health efforts. Additionally, experts like Dr. Mir Ali and nutritionist Monique Richard advocate for reducing UPF consumption by incorporating healthier options into diets and encouraging home-cooked meals. Richard suggests practical strategies, such as swapping sugary drinks for infused water and choosing minimally processed foods, to help individuals make healthier dietary choices amid the prevalence of UPFs.
Published: Nov 25 2025, 1 ameznews.inA recent study published in JAMA Network Open indicates that increased physical activity in midlife and late life may significantly reduce the risk of all-cause dementia and Alzheimer's disease. As of 2020, over 55 million people worldwide were living with dementia, a number projected to rise to 78 million by 2030. The research, which analyzed data from the Framingham Heart Study involving approximately 4,300 participants, found no significant link between physical activity in early adulthood and dementia risk. Lead researcher Phillip H. Hwang emphasized that staying active later in life could be just as crucial for dementia prevention as being active in midlife. Experts like neurologist Clifford Segil and neuropsychologist Raphael Wald echoed the study's findings, highlighting the importance of maintaining physical activity throughout life to mitigate dementia risk, alongside other health benefits. The study underscores the need for ongoing research into lifestyle factors that may influence cognitive health as we age.
Published: Nov 24 2025, 11 pmeznews.inResearchers at the University of Pennsylvania have uncovered how hydralazine, a long-established blood pressure medication, could potentially combat glioblastoma, an aggressive brain tumor. Previously, the drug's mechanism of action was unknown, but the study revealed that hydralazine works by inhibiting the enzyme 2-aminoethanethiol dioxygenase (ADO), which is crucial for blood vessel relaxation and may also play a role in tumor growth. When glioblastoma cells were treated with hydralazine, they entered a state of senescence, significantly slowing their growth. While the findings are promising, experts caution that further research is necessary before hydralazine can be considered a viable treatment option. Dr. Walavan Sivakumar noted that the discovery opens a new avenue for brain cancer therapies, particularly given hydralazine’s established safety profile and low cost. However, Dr. Nicholas Klaiber raised concerns about the potential for tumor resistance and the need for continuous treatment.
Published: Nov 23 2025, 1 pmeznews.inA recent study published in *JAMA Network Open* has revealed a significant link between obstructive sleep apnea (OSA) and cerebral microbleeds, which can increase the risk of dementia and stroke. The research, involving over 1,400 participants over eight years, found that individuals with moderate to severe OSA were more than twice as likely to develop microbleeds compared to those without the condition. The study highlights the need for early diagnosis and treatment of OSA to mitigate potential brain health risks. Researchers noted that cerebral microbleeds are associated with chronic blood product buildup in the brain and are more prevalent in older adults. Despite its insights, the study's focus on a Korean population limits its generalizability, and further research is necessary to explore the mechanisms behind OSA's impact on brain health. Experts emphasize the importance of preventive measures to improve sleep quality and reduce the chances of developing serious neurological conditions.
Published: Nov 22 2025, 5 pmeznews.inRecent research highlights the significant health risks associated with the consumption of ultra-processed foods, linking them to inflammatory bowel disease (IBD), lung cancer, and diabetes. The Food Standards Agency notes that diets high in these foods can exacerbate IBD symptoms and increase the risk of Crohn's disease. A study revealed that higher intake of ultra-processed foods correlates with a 41% increased risk of lung cancer. Additionally, even small amounts of processed meats can elevate diabetes risk; for instance, consuming just one hot dog daily raises the chance of type 2 diabetes by 11%. A recent study focused on young adults found that increased consumption of ultra-processed foods is associated with a higher risk of prediabetes. Experts advocate for a Mediterranean-style diet rich in fruits, vegetables, and whole grains as a healthier alternative to mitigate these risks.
Published: Nov 22 2025, 1 ameznews.inAs Thanksgiving approaches, health experts caution that the holiday can pose various risks, including foodborne illnesses, medication interactions, and overeating. Foods commonly served may affect medications like blood thinners and antibiotics; for instance, vitamin K in turkey can influence blood clotting, while dairy can hinder antibiotic effectiveness. Additionally, alcohol and grapefruit juice may interact negatively with numerous prescriptions. To mitigate these risks, dietitian Michelle Routhenstein recommends consulting healthcare professionals about potential interactions and suggests thoughtful meal planning, such as eating smaller meals beforehand and avoiding skipping breakfast. Proper food handling is critical to prevent contamination, with guidelines for safely thawing and cooking turkey. Encouraging mindful eating and physical activity, Routhenstein emphasizes that Thanksgiving should be about enjoyment and connection, not guilt, and promotes viewing holiday meals as part of a broader, sustainable lifestyle rather than a temporary indulgence.
Published: Nov 21 2025, 10 pmFor the fastest, latest, not so wokest news, 'experts say' you need to visit Eznews
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