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Researchers at the Institute of Cancer Research in London have developed a groundbreaking test that predicts colorectal cancer risk in patients with inflammatory bowel disease (IBD) with over 90% accuracy. IBD patients are already screened for colorectal cancer every one to three years through colonoscopies, but detecting pre-cancerous cells can be challenging. The new test, detailed in the journal *Gut*, analyzes genetic changes in biopsy samples to determine cancer risk. Professor Trevor Graham, the study's senior author, emphasized that this test could help identify patients who require surgery to remove their bowel, thus preventing unnecessary procedures for those at low risk. Experts in the field have praised the study's potential to enhance patient care by reducing invasive procedures and anxiety surrounding cancer risk. Future clinical trials aim to validate the test's effectiveness, with hopes of integrating it into NHS practices. 
Published: Feb 04 2025, 10 pmeznews.inA recent study published in the journal *PNAS* reveals that the timing of interventions to combat age-related cognitive decline may be crucial, with specific age windows identified as optimal for effectiveness. Researchers analyzed neuroimaging data from over 19,000 individuals, finding that brain networks begin to degrade around age 44, accelerating through the 60s and stabilizing by age 90. Lead author Dr. Lilianne Mujica-Parodi emphasized the importance of early intervention, likening brain neurons to a city reliant on a stable power supply. The study also highlighted the role of neuronal insulin resistance and the potential of ketones as an alternative energy source for aging brains. Experts, including Dr. Verna Porter and Dr. Gary Small, support the idea that a ketogenic diet may offer protective benefits against cognitive decline, suggesting further research into its long-term efficacy in at-risk populations.
Published: Mar 12 2025, 12 ameznews.inA recent study published in *PNAS* suggests that an imbalance in gut bacteria could be linked to the severity of Multiple Sclerosis (MS), which affects approximately 2.9 million people globally. Researchers, led by Dr. Ashutosh K. Mangalam from the University of Iowa, found that MS patients exhibited higher levels of the bacterium *Blautia* and lower levels of *Prevotella*, indicating a potential predictive relationship between these bacteria and disease severity. In a mouse model, those given *Blautia* developed increased gut inflammation and worse MS-like symptoms compared to other groups. Mangalam emphasized the need for further research to confirm these findings and explore the implications of gut health on MS management, suggesting that while probiotics may help, dietary changes may be more beneficial. Experts agree that a better understanding of the gut microbiome could inform lifestyle recommendations for MS patients, although more extensive human studies are necessary.
Published: Mar 10 2025, 9 pmeznews.inA recent study has highlighted the potential of strength training as an effective strategy to combat insomnia in older adults, who face significant sleep issues, with up to 50% affected globally. Researchers analyzed data from over 2,000 participants aged 60 and above, revealing that resistance training led to the most substantial improvements in sleep quality, with participants reporting a 5.75-point reduction in their Pittsburgh Sleep Quality Index (PSQI) scores. This study, which included various exercise patterns such as aerobic and flexibility training, underscores the importance of physical activity in enhancing sleep quality. Experts emphasize that while resistance training shows promise, it should be part of a broader approach to managing insomnia, as poor sleep can lead to cognitive decline and increased health risks. The findings call for further research to explore optimal exercise protocols and the long-term effects of these interventions on sleep and overall health in an aging population.
Published: Mar 09 2025, 1 pmeznews.inRecent research from the University of Toronto has highlighted a potential link between low-carb diets, gut bacteria, and an increased risk of colorectal cancer, particularly in younger populations. The study, conducted on mice, examined the effects of different diets and bacterial strains on the gut microbiome. It found that a low-carb, low-fiber diet combined with a specific strain of *Escherichia coli* significantly increased polyp development in the colon, a precursor to cancer. The low-carb diet thinned the protective mucus layer in the colon, allowing harmful bacteria to damage DNA and promote inflammation. While the findings raise concerns, researchers noted that adding fiber to the diet could mitigate tumor formation and inflammation. Experts emphasize the need for further research to understand these connections in humans, particularly regarding the types of fiber that may protect gut health.
Published: Mar 08 2025, 9 pmeznews.inResearch from the University of Cambridge suggests that aspirin may play a role in preventing cancer metastasis by enhancing the immune response. In a mouse study, aspirin reduced the production of thromboxane A2 (TXA2), a clotting factor that suppresses immune T cells, allowing them to target and destroy spreading cancer cells. This discovery highlights a potential therapeutic window where early-stage cancer cells are vulnerable to immune attacks. While the findings are promising, experts emphasize the need for clinical trials to validate these results in human patients. Aspirin's accessibility and low cost could offer a significant advantage over existing therapies, but it is essential to consult a healthcare professional before starting treatment due to potential side effects, including gastrointestinal issues and bleeding risks. Current trials, such as the Add-Aspirin study, aim to further investigate aspirin's effectiveness in preventing cancer recurrence.
Published: Mar 08 2025, 2 ameznews.inNew research published in *Life Metabolism* has unveiled a potential link between intermittent fasting and a reduced risk of blood clots, which can lead to serious health issues such as heart attacks and strokes. The study, involving 160 participants with coronary artery disease, demonstrated that intermittent fasting may inhibit platelet activation and clot formation by enhancing the production of indole-3-propionic acid (IPA) by gut microorganisms. This metabolite appears to play a crucial role in preventing blood clotting, with results indicating that fasting participants had higher IPA levels and better outcomes in mouse models of ischemia. Experts suggest that these findings could pave the way for non-pharmacological approaches to manage thrombosis risk, potentially positioning intermittent fasting as a complementary therapy for cardiovascular disease. However, researchers emphasize the need for further studies to explore the long-term effects and mechanisms behind these findings, as well as to confirm their applicability to diverse populations.
Published: Mar 06 2025, 10 pmeznews.inRecent research highlights the critical role of diet and exercise in promoting longevity and enhancing health span. A study published in December 2024 indicates that young adults consuming high amounts of processed foods and sugary drinks experience accelerated biological aging, while diets rich in fruits and vegetables correlate with slower aging. Additionally, a review in the *Canadian Medical Association Journal* suggests that moderate exercise can reduce the risk of death in older adults by 31%. Supplementation with omega-3 and vitamin D, combined with regular exercise, further lowers age-related health risks, according to findings from a study published in *Nature Aging*. Moreover, the significance of maintaining healthy nutrient levels, such as NAD+, is underscored by ongoing research, indicating that dietary choices and physical activity can profoundly influence both lifespan and quality of life. These studies collectively reinforce the importance of lifestyle modifications for healthier aging.
Published: Mar 06 2025, 7 pmeznews.inA recent study from the University of Calgary has revealed that women experiencing multiple symptoms during menopause may face an increased risk of cognitive decline and behavioral impairments associated with dementia as they age. Menopause, typically occurring around age 52, can bring symptoms such as hot flashes, mood swings, and sleep disturbances, which significantly affect quality of life for many women. The research, published in *PLOS One*, suggests that a higher burden of menopausal symptoms correlates with poorer cognitive function. While hormone therapy was associated with lower behavioral impairment scores, its direct impact on cognitive performance remains inconclusive. Experts emphasize the importance of early intervention, whether through hormone therapy or lifestyle changes, to mitigate dementia risk. The study highlights the need for further research to understand the relationship between menopause and cognitive health, advocating for greater awareness and tailored care for women's unique health needs during this transitional phase.
Published: Mar 06 2025, 3 ameznews.inResearchers have made significant strides in treating corneal blindness through an experimental stem cell therapy known as cultivated autologous limbal epithelial cells (CALEC). This innovative treatment aims to address unilateral limbal stem cell deficiency (LSCD), a condition affecting over 10 million people globally. In a recent clinical trial led by Dr. Ula Jurkunas at Mass Eye and Ear, 50% of the 15 participants experienced complete cornea restoration within three months, with success rates increasing to 79% at the 12-month mark. The CALEC procedure involves harvesting limbal cells from a healthy eye, expanding them in a lab, and transplanting them into the damaged eye, proving safer than traditional methods. The study reported no serious complications, highlighting CALEC's high safety profile. Future phases of the trial aim to explore allogenic approaches and test CALEC against other treatments, potentially revolutionizing care for patients suffering from corneal damage.
Published: Mar 05 2025, 5 pmeznews.inA recent study suggests that engaging in daily moderate-to-vigorous physical activity may significantly lower the risk of neuropsychiatric diseases, including dementia, depression, and stroke. Researchers analyzed data from over 73,000 adults, finding that those who met specific energy expenditure levels were 14% to 40% less likely to develop these conditions compared to less active individuals. The study utilized objective accelerometer data to measure activity levels, addressing potential biases present in self-reported data. Co-lead author Dr. Jia-Yi Wu emphasized the importance of physical activity as a modifiable risk factor, particularly for aging populations. The findings highlight a dose-response relationship between exercise and brain health, reinforcing public health guidelines that advocate for increased physical activity to mitigate the risks associated with neuropsychiatric disorders. Experts not involved in the study echoed its significance, noting the critical role of lifestyle changes in promoting neurological health.
Published: Mar 05 2025, 12 amFor the fastest, latest, not so wokest news, 'experts say' you need to visit Eznews
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